The Vice Chancellor (VC) is the academic and administrative leader of the institution. S/he establishes and implements a university strategic management plan for efficient use of its resources, human, fiscal, and capital, in compliance with the University of Botswana Act and Statutes. The VC therefore enables the realisation of the vision and mission of the University by coordinating the development of its policies, plans and programmes, based on the strategic overview of the University and its environment.

The Deputy Vice Chancellor, Academic Affairs (DVC AA) provides leadership and advises the Vice Chancellor in the academic area where s/he is responsible for academic policy, plans and formulation and implementation of teaching, research and service programmes and the overall direction of academic support services. The DVC AA is therefore responsible for the development and implementation of effective strategies for teaching and learning across the University and ensures that University becomes aware of best practices and developments in these areas.

The Deputy Vice Chancellor, Finance and Administration (DVC F&A) provides leadership in the finance and administration areas and provide strategic and policy advice to the Vice Chancellor on financial and administrative matters. S/he is responsible for policy formulation and implementation of the financial, administration, information technology, human resources, security, domestic services, general services and the maintenance of physical resource functions of the University.

The Deputy Vice Chancellor, Student Affairs (DVC SA) provides leadership and advises the Vice Chancellor on matters of student affairs, and develops policy for all aspects of student life. Among others, the DVC SA provides consultative and other mechanisms to stimulate dialogue between the University authorities and the student body and promote good government and peace across the University.