Staff Profiles

MBChB, MMed Path, PhD, FCPath (ECSA)

Lynnette T. Kyokunda is Head of Department, Pathology at the University of Botswana (UB) and Anatomic Pathologist with 18 years’ experience. She served as Head, Department of Pathology, Makerere University College of Health Sciences, Kampala, Uganda and later as Director of Pathology and Laboratory Medicine at King Faisal Hospital in Kigali, Rwanda. She was Uganda Co-PI on the NCI/NIH funded Mid-Region AIDS and Cancer Specimen Resource. Her research focus has been on oncogenic viruses and their role in lymphoma development also looking at micro RNAs and molecular classifications of malignant lymphomas and their prognostic relevance. Her current focus and interest are in other HIV/AIDS associated malignancies as well as cancer arising in HIV/AIDS patients on ART. She is also co-investigator on an international study investigating tumor microenvironment in breast cancer focusing on identifying new molecular signatures for development of new-targeted therapies. She has served as external examiner in Uganda, Kenya, Tanzania and South Africa. She is involved in graduate research supervision, teaches both graduate and undergraduate pathology including research methods. She is currently supervising one post-doctoral fellow, PhD and MMed residents. Has published widely in cancer and infectious disease and is the current UB Faculty of Medicine Research and Publication Chair. She serves on a number of University Committees and has chaired two successful MPhil defense.

MBBS

SOM 301

• Autopsy & forensic Pathology
• Pathology  & diagnostic methods
• Atherosclerosis, thrombosis & embolism
• Natural History of cancer

MMed

GME 603/4/703: MMed Part I preparation

GME 681/2/: Introduction to Anatomical Pathology

GME 790/1/2/3: Dissertation

GME 781/2/3/4: Intermediate Anatomic Pathology

GME 706/794: Presentation & Defense of Dissertation

GME 707: MMed Part II preparation

GME 785/6: Advanced Anatomic Pathology

Supervision MPhil/PhD

Cancer (Basic, Clinical and Molecular pathology): Lymphoma, Cervical, Breast, Oropharyngeal, Prostate and Colorectal cancer, Multiple Myeloma, Osteoblastic Osteosarcoma, Kaposi sarcoma, Endometrial cancer. Identification of new molecular prognostic markers.

Infectious Disease: Cryptococcal Infection and Malaria

Health Systems Management: COVID-19 Impact

Laboratory Quality Management: Accuracy of H & E in Hodgkin's lymphoma, Kaposi sarcoma, Criteria based Audit of Anatomic Pathology

1. Immunohistochemistry Analysis of MMR gene expression profile in Endometrial cancer Biopsy Specimen

2. Accuracy of H & E in the Diagnosis of Kaposi sarcoma

3. Histopathology and prevalence of Helicobacter Pylori Gastritis

4. p16 Immunohistochemistry analysis and squamous intra epithelial lesions

5. Clinicopathological characteristics of Prostate Cancer in Botswana in relation to HIV.

6. Investigation of genetic and non-genetic determinants of breast cancer.

Tumwine LK, et. al. B cell non Hodgkin lymphoma in Uganda: an immunohistochemistry appraisal on tissue microarray. Hum. Pathol 2008; 39(6): 817-23.

Tumwine LK, et. al. Immunohistochemical and other prognostic factors in B cell non Hodgkin lymphoma patients, Kampala, Uganda. BMC Clinical Pathology 2009, 9: 11.

Rodig SJ et al. The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker for identifying c-MYC translocated lymphomas. Haematologica. 2010 Dec;95(12):2056-62. Epub 2010 Sep 7.

Piccaluga PP et al. Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes. Blood. 2011 Mar 31;117(13):3596-608. Epub 2011 Jan 18.

Piccaluga PP, et al. Virus-encoded micro RNA contributes to the molecular profile EBV-positive Burkitt lymphoma. Oncotarget 2015 Jul 31.